892 available at: http://ijph.tums.ac.ir genetic of alzheimer's disease: a narrative review article

background : alzheimer's disease (ad) is one of the most common problems for old peoples. etiology of ad is not clear, but genetic factors play a major role in determining a person's risk to develop ad. twin and family studies con-firm that ad has a genetic basis.ad genetics has been split into two broad categories: early-onset and late-onset. eo-ad cases are inherited in an autosomal dominant pattern. in this form, dominant mutations in genes like app, psen-1 and psen-2 associated with ad. this study aimed to consider the role of genetic in ad. method : at the first, most of the references in relation with genetic basis of ad searched from the following web-sites: pubmed, science direct, wiley & sons (1995-2014). then, the most common genes and their affects described briefly. results : aging is the most obvious risk factor for developing ad. there is a genetic basis for ad, of course this rela-tion is not complete but it is significant. conclusion : more than thousand genes studied in relation with alzheimer's disease. against the improvements in understanding different aspects of ad, the accurate genetic foundation of ad remain unclear.